Sequenced-based GWAS for linear classification traits in Belgian Blue beef cattle reveals new coding variants in genes regulating body size in mammals

Table 1 LD-based credible sets (CS) identified by multiple-trait genome-wide association study (MT-GWAS) (r² > 0.90)

QTL-region	Number of SNPs in MT-GWAS1	Number of SNPs in MT-GWAS2	Number of SNPs in both CS	Span of CS in bp^a	Number of genes	Genes present in CS
BTA3:95 Mb	2	2	2	1,733,382	2	SCP2^, RNF11^
BTA4:112 Mb	57	–	57	420,567	3	ENSBTAG00000052473, CUL1, EZH2
BTA5:106 Mb	6	–	6	6741	1	CCND2
BTA6:36 Mb	1	1	1	1	0
BTA14:76 Mb	116	116	116	266,423	1	WWP1^*
BTA16:58 Mb	11	11	11	251,954	1	PAPPA2^*
BTA18:2 Mb	86	86	86	268,177	11	ENSBTAG00000052687^, ENSBTAG00000053632^, ENSBTAG00000051242^, IL34^, FUK^, ST3GAL2^, DDX19A^, DDX19B^, AARS^, EXOSC6^, CLEC18C^*
BTA19:49 Mb	5	5	5	1,649,747	3	CDC27^, MRC2^, KCNH6^*
BTA23:10 Mb	6	–	6	30,728	1	ARMC12
BTA25:26 Mb	–	20	20	647,161	18	ENSBTAG00000048352, ENSBTAG00000051451, NUPR1, GDPD3, YPEL3, FAM57B, C16orf92, SEZ6L2, ASPHD1, MVP, SPN, CD2BP2, TBC1D10B, MYLPF, SEPT1, ZNF48, ZNF771, DCTPP1
BTA26:45 Mb	4	14	18	474,978	2	ENSBTAG00000007010, ADAM12

MT-GWAS1 MT-GWAS with traits related to height and body dimensions, MT-GWAS2 MT-GWAS with traits related to muscular development
^*Genes present in CS from both MT-GWAS are indicated with a star (other are specific to a single MT-GWAS)
^aThe start and end of each QTL region can be found in Additional file 3: Tables S12–S22 and S24–S28 that provide the detailed CS

ISSN: 1297-9686