The genetics of gaits in Icelandic horses goes beyond DMRT3, with RELN and STAU2 identified as two new candidate genes

Table 1 Results from the haplotype analysis for SNPs on ECA4 and 9 associated with pace score

Chr	Hap. ID	Haplotypes (SNP number^a)				Freq	Coeff	p-value	Sim. p-value	\({{\sigma }}_{{p}}^{2}\) ratio
ECA4		1		2^b
	R	C		C		0.54	0.51	< 0.001	< 0.001	0.044
	r	A		A		0.45	− 0.51	< 0.001	< 0.001	0.044
ECA9		1	2	3^c	4
	S	A	A	A	G	0.90	0.89	< 0.001	< 0.001	0.044
	s	G	C	G	A	0.08	− 0.89	< 0.001	< 0.001	0.044

Chr: chromosome; Hap. ID: haplotype identification letters to distinguish between different haplotypes; Freq: haplotype frequency; Coeff: coefficient, estimated effect of the haplotype on the pace score from a GLM regression in the haplotype analysis; Sim. p-value: p-value adjusted by using 100,000 permutations; \({\sigma }_{p}^{2}\) ratio: ratio of phenotypic variance explained by the haplotypes
^aSNP numbers are in bp positional order
^bThe top SNP on ECA4 is number 2 in the positional order, where the reference allele is A and alternate allele is C
^cThe top SNP on ECA9 is number 3 in the positional order, where the reference allele is G and alternate allele is A

ISSN: 1297-9686