Longitudinal genomic analyses of automatically-recorded vaginal temperature in lactating sows under heat stress conditions based on random regression models

Wen, Hui; Johnson, Jay S.; Freitas, Pedro H. F.; Maskal, Jacob M.; Gloria, Leonardo S.; Araujo, Andre C.; Pedrosa, Victor B.; Tiezzi, Francesco; Maltecca, Christian; Huang, Yijian; Schinckel, Allan P.; Brito, Luiz F.

doi:10.1186/s12711-023-00868-1

Genetics Selection Evolution

Table 4 Significantly enriched (P < 0.05) KEGG pathways using uniquely enriched positional candidate genes for Tv for the four heat stress (HS) time-periods

From: Longitudinal genomic analyses of automatically-recorded vaginal temperature in lactating sows under heat stress conditions based on random regression models

Time-period^a	Term	Number of unique genes^b	Total number of genes^c	P-value	FDR
HS time-period 1	ssc04137: Mitophagy—animal	17	64	0.047	0.195
(T_V: 39.741 ± 0.724DP: 22.080 ± 2.060)
HS time-period 2	ssc04744: Phototransduction	7	68	0.006	0.012
(T_V: 39.134 ± 0.620DP: 22.844 ± 2.084)	ssc04727: GABAergic synapse			0.020	0.012
	ssc05032: Morphine addiction			0.021	0.012
	ssc04713: Circadian entrainment			0.022	0.012
	ssc04724: Glutamatergic synapse			0.025	0.012
	ssc04725: Cholinergic synapse			0.025	0.012
	ssc04726: Serotonergic synapse			0.026	0.012
	ssc04380: Osteoclast differentiation			0.028	0.012
	ssc04728: Dopaminergic synapse			0.029	0.012
	ssc04926: Relaxin signaling pathway			0.029	0.012
	ssc04371: Apelin signaling pathway			0.031	0.012
	ssc04723: Retrograde endocannabinoid signaling			0.033	0.012
	ssc05034: Alcoholism			0.038	0.012
	ssc04062: Chemokine signaling pathway			0.041	0.012
	ssc05167: Kaposi sarcoma-associated herpesvirus infection			0.044	0.012
	ssc05170: Human immunodeficiency virus 1 infection			0.049	0.012
HS time-period 3	ssc04916: Melanogenesis	18	70	< 0.001	0.014
(T_V: 39.771 ± 0.729 DP: 23.843 ± 2.478)	ssc04921: Oxytocin signaling pathway			0.001	0.016
	ssc04934: Cushing syndrome			0.001	0.016
	ssc04213: Longevity regulating pathway—multiple species			0.002	0.035
	ssc05217: Basal cell carcinoma			0.003	0.035
	ssc04211: Longevity regulating pathway			0.005	0.049
	ssc05410: Hypertrophic cardiomyopathy			0.005	0.049
	ssc05414: Dilated cardiomyopathy			0.006	0.049
	ssc04371: Apelin signaling pathway			0.012	0.067
	ssc04550: Signaling pathways regulating pluripotency of stem cells			0.013	0.067
	ssc04261: Adrenergic signaling in cardiomyocytes			0.013	0.067
	ssc05224: Breast cancer			0.013	0.067
	ssc05226: Gastric cancer			0.014	0.067
	ssc04150: mTOR signaling pathway			0.015	0.067
	ssc04390: Hippo signaling pathway			0.015	0.067
	ssc05225: Hepatocellular carcinoma			0.016	0.068
	ssc04310: Wnt signaling pathway			0.017	0.068
	ssc05207: Chemical carcinogenesis—receptor activation			0.025	0.091
	ssc05205: Proteoglycans in cancer			0.026	0.091
	ssc04714: Thermogenesis			0.032	0.108
	ssc04710: Circadian rhythm			0.042	0.136
HS time-period 4	ssc00240: Pyrimidine metabolism	11	51	0.018	0.006
(T_V: 40.125 ± 0.687 DP: 23.226 ± 1.996)	ssc04924: Renin secretion			0.023	0.006
	ssc04742: Taste transduction			0.024	0.006
	ssc01232: Nucleotide metabolism			0.027	0.006
	ssc05032: Morphine addiction			0.031	0.006
	ssc03040: Spliceosome			0.042	0.006
	ssc00230: Purine metabolism			0.043	0.006

HS: heat stress; FDR: false discovery rate
^aTime-period: mean ± standard deviation was showed for each stage: 1: from 23h00 to 06h30, 2: from 06h30 to 09h30, 3: from 09h30 to 18h30, and 4: from 18h30 to 23h00
^bNumber of unique genes: number of genes was uniquely enriched in each HS stage
^cTotal number of genes: number of all genes enriched in each HS stage

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ISSN: 1297-9686

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