Longitudinal genomic analyses of automatically-recorded vaginal temperature in lactating sows under heat stress conditions based on random regression models

Table 5 Significantly enriched (P < 0.05) KEGG pathways using uniquely enriched candidate genes identified for the three environmental gradient classes

Environmental gradient (EG) class^a	Term	Number of unique genes^b	Total number of genes^c	P-value	FDR
EG class 1	ssc00514: Other types of O-glycan biosynthesis	20	61	0.016	0.027
(T_V: 39.535 ± 0.734 DP: 18.217 ± 1.176)	ssc04666: Fc gamma R-mediated phagocytosis			0.031	0.027
(T_V: 39.535 ± 0.734 DP: 18.217 ± 1.176)	ssc04550: Signaling pathways regulating pluripotency of stem cells			0.047	0.027
EG class 2	ssc04973: Carbohydrate digestion and absorption	1	86	0.016	0.034
(T_V: 39.687 ± 0.743 DP: 22.403 ± 1.283)	ssc04978: Mineral absorption			0.018	0.034
	ssc04976: Bile secretion			0.028	0.034
	ssc04114: Oocyte meiosis			0.040	0.034
	ssc04110: Cell cycle			0.041	0.034
EG class 3	ssc00760: Nicotinate and nicotinamide metabolism	9	82	0.028	0.076
(T_V: 39.874 ± 0.765DP: 25.310 ± 0.743)	ssc04080: Neuroactive ligand-receptor interaction			0.030	0.076
(T_V: 39.874 ± 0.765DP: 25.310 ± 0.743)	ssc04730: Long-term depression			0.046	0.076

EG: environmental gradient; FDR: false discovery rate
^aStage: mean ± standard deviation of vaginal temperature (Tv) and dew point (DP) for each environmental gradient (standardized dew point) class (no to mild heat stress: − 3.5 to 1.5; moderate heat stress: − 1.5 to 0.5; severe heat stress: 0.5–2.5)
^bNumber of unique genes: number of genes was uniquely enriched in each EG class
^cTotal number of genes: number of all genes enriched in each EG class

ISSN: 1297-9686