Advances in understanding the genetic architecture of antibody response to paratuberculosis in sheep by heritability estimate and LDLA mapping analyses and investigation of candidate regions using sequence-based data

Table 5 Annotation impacts and effects of WGS SNPs located within the interval between 23.77 and 25.83 Mb on OAR 20

Annotation impact	Annotation effect	n SNP	n effects	\(-{{\text{log}}}_{10}\left({\text{Pvalue}}\right)\)	n SNP > 15
High	Stop gained	5	26	4.8	0
	Splice donor variant	2	4	1.4	0
	Splice acceptor variant	1	13	1.1	0
	Stop lost	1	8	0.3	0
Moderate	Missense variant	356	2042	14.8	0
Low	Synonymous variant	324	1849	17.5	3
	Splice region variant	80	342	8.8	0
	Initiator codon variant	1	1	4.0	0
	5′ UTR premature start codon gain variant	47	89	9.3	0
Modifier	Intergenic region	17,333	17,333	20.2	314
	Upstream gene variant	4017	7537	19.9	74
	Downstream gene variant	3255	6202	19.0	27
	Intron variant	16,791	130,561	19.0	65
	Non coding transcript exon variant	214	214	13.8	0
	5′ UTR variant	250	483	10.3	0
	3′ UTR variant	422	1209	7.8	0

nSNP: number of WGS SNPs in the region; n effects: number of corresponding effects; -log₁₀(P-value) negative logarithm of the P-value of the most significant SNP; n SNP > 15: number of WGS SNPs exceeding the significance threshold \(-{{\text{log}}}_{10}\left({\text{Pvalue}}\right)>15\)

ISSN: 1297-9686