Fig. 6

UpSet plot showing the intersection of significant XPEHH Z-scores between the different sequencing depths. a Results are presented from each depth of coverage, imputed with each reference panel, for Z-scores > 4. b Results are presented from each depth of coverage, imputed with each reference panel, for Z-scores < − 4. For both panels, the main bar plot indicates the count of intersecting significant variants between the datasets highlighted with points in the matrix beneath. Each row in the matrix corresponds to a specific dataset and the label indicates the reference panel used (full, panel 1, or panel 2), and the sequencing depth of the data (0.9X, 3.8X, 9.6X, 17.4X, or 43.5X). The bar plot to the left indicates the number of significant variants identified for the corresponding dataset, and is coloured according to the reference panel used. If no significant variant was identified for a dataset then it was not included in the matrix. The inset in panel b shows a box plot of Z-scores < − 4 for each sequencing depth, with a T test p value comparing the means of the two highest counts (0.9X and 17.4X)