Table 7 List and functions of the four genes annotated in three heterozygous regions (chr10_a, chr19_a, and chr19_b) shared by the four populations
Region | Gene name | Protein name | General function | References |
|---|---|---|---|---|
chr10_a | ctnna2 | catenin alpha 2 | Enables actin filament binding activity, and involved in negative regulation of Arp2/3 complex-mediated actin nucleation. Regulation of neuron migration and of neuron projection development. Implicated in brain malformations. Seems implicated in vertebral development(/deformities) in Yunlong grouper | |
chr19_a | smarca5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II | |
frem2 | FRAS1-related extracellular matrix protein 2 | Plays a role in epidermal-dermal interactions—> important for the integrity of skin and renal epithelia | [128] zebrafish | |
chr19_b | pou4f2 | POU domain, class 4, transcription factor 2-like | May be involved in maintaining visual system neurons in the retina, and in the lateral line. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. Seems link to cardiac development in zerafish |