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Fig. 4 | Genetics Selection Evolution

Fig. 4

From: Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability

Fig. 4

Nonsense variant in the MMUT gene within the MTRDHH1 genomic region. a Scatter plot showing the correlation between MTRDHH1 status (NC_040271.1, OAR20:22,996,023–24,950,669 extended from each side by 1 Mb) and genotype of variants from 100 whole-genome sequenced animals. Each dot represents one variant. b Position of the MMUT gene within the MTRDHH1 haplotype. Black bars indicate the first and the last markers of the Illumina Ovine SNP50 BeadChip defining the limits of MTRDHH1 [see Additional file 5: Table S4]. c MMUT gene structure (GeneID: 101,122,731) and localization of the MMUT C > T polymorphism identified in the sixth exon (XM_004018875.4, UTR: untranslated region; CDS: coding sequence). d MMUT protein (XP_004018923.1) with methylmalonyl-CoA mutase (PF01642) and B12-binding (PF02310) Pfam domain annotations (UniProtKB accession number: A0A6P3T7X3_SHEEP). The mutation creates a premature stop-gain at amino-acid position 409

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Genetics Selection Evolution

ISSN: 1297-9686