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Fig. 5 | Genetics Selection Evolution

Fig. 5

From: Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability

Fig. 5

Effects of the MMUT nonsense variant. a Association of MMUT SNV genotypes with MTRDHH1 status. + / + : non-carriers; MTRDHH1/ + : heterozygous carriers and MTRDHH1/MTRDHH1: homozygous carriers (Fisher’s exact test, p < 0.001, without the homozygous MTRDHH1 carriers). b Time distribution of dead lambs in the pre-weaning period depending on MMUT SNV genotype and lambing place. c MMUT SNV genotype effect on lamb birth weight born on the experimental farm. Affected homozygous lambs are in red (A/A genotype). d MMUT gene expression at mRNA and e protein levels in kidney and liver depending on MMUT SNV genotypes. f Methylmalonic acid dosage by ELISA quantification in blood plasma and urine collected from lambs with different genotypes at the MMUT SNV

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Genetics Selection Evolution

ISSN: 1297-9686