Searching for homozygous haplotype deficiency in Manech Tête Rousse dairy sheep revealed a nonsense variant in the MMUT gene affecting newborn lamb viability

Table 2 List of Manech Tête Rousse deficient homozygous haplotypes

Haplotype	OAR	^aNumber of markers	^bPosition (Mb)	^cHeterozygous carrier frequency (%)	Number of homozygotes
Haplotype	OAR	^aNumber of markers	^bPosition (Mb)	^cHeterozygous carrier frequency (%)	Exp.	Obs.	Deficit (%)	Poisson P-value
MTRDHH1	20	32	23.0–25.0	9.7	13	0	100	\({2.9}\times{10}^{-6}\)
MTRDHH2	1	66	251.9–256.4	8.7	10	0	100	\({3.8}\times{10}^{-5}\)
MTRDHH3	1	39	103.8–106.6	7.8	9	0	100	\({9.6}\times{10}^{-5}\)
MTRDHH4	10	26	30.5–31.5	8.7	11	1	91	\({1.5}\times{10}^{-4}\)
MTRDHH5	13	29	64.3–67.2	16.6	49	8	84	\({5.3}\times{10}^{-13}\)

OAR Ovis aries chromosome
Exp Expected
Obs Observed
^aDetails on the MTRDHH haplotypes and SNP composition are in Additional file 5: Table S4
^bPosition on the ovine genome assembly Oar_rambouillet_v1.0
^cFrequency of carriers in the entire genotyped population (n = 6845)

ISSN: 1297-9686