A common regulatory haplotype doubles lactoferrin concentration in milk

Table 1 Summary phenotypic and heritability statistics for Lf concentration

Period	NP	\(\text {Mean} \pm \text {SD}\)	Median	Skew	NG	\(\mathsf {h^2_{\text {SNP}} \pm \text {SE}}\)	LRT Pval
Peak	621	\(\mathsf {98.3 \pm 88.2}\)	70.0	2.37	595	\(\mathsf {0.364 \pm 0.102}\)	\({3.21 \times 10^{-9}}\)
LogPeak	621			− 0.09	595	\(\mathsf {0.416 \pm 0.102}\)	\({1.34 \times 10^{-12}}\)
Mid	648	\(\mathsf {201.3 \pm 139.7}\)	173.0	1.20	622	\(\mathsf {0.151 \pm 0.081}\)	\({1.77 \times 10^{-4}}\)
LogMid	648			− 0.94	622	\(\mathsf {0.253 \pm 0.094}\)	\({1.66 \times 10^{-7}}\)
Late	611	\(\mathsf {186.5 \pm 113.8}\)	163.0	1.53	588	\(\mathsf {0.335 \pm 0.099}\)	\({3.14 \times 10^{-13}}\)
LogLate	611			− 0.71	588	\(\mathsf {0.413 \pm 0.103}\)	\({<1 \times 10^{-16}}\)
Agg	700	\(\mathsf {7.0 \pm 81.8}\)	− 3.0	1.48	679	\(\mathsf {0.433 \pm 0.091}\)	\({<1\times 10^{-16}}\)

Concentrations are shown in units of mg/L. The Agg period represents the aggregated phenotype produced using a repeated-measures model in AS-REML. The Skew column contains the estimated sample skewness for each phenotype. The NP column shows the number of phenotyped animals recorded for each sampling period; the NG column is the number of animals both phenotyped and genotyped. The LRT Pval column shows the p-value for \(H_0{:}h^2_{\text {SNP}}=0\), determined using a likelihood ratio test

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