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Genetics Selection Evolution

Open Access

The porcine Major Histocompatibility Complex and related paralogous regions: a review

  • Patrick Chardon1Email author,
  • Christine Renard1,
  • Claire Rogel Gaillard1 and
  • Marcel Vaiman1
Genetics Selection Evolution200032:109

Received: 18 November 1999

Accepted: 17 January 2000

Published: 15 March 2000


The physical alignment of the entire region of the pig major histocompatibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced. Over one hundred genes have been characterised, including the classical class I and class I-related genes, as well as the class II gene families. These results in swine provide new evidence for the striking conservation during the evolution of a general MHC framework, and are consistent with the location of the class I genes on segments referred to as permissive places within the MHC class I region. Recent results confirm the involvement of the SLA region in numerous quantitative traits.


pigmajor histocompatibility complexphysical mapperformanceparalogous regions

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Authors’ Affiliations

Laboratoire de radiobiologie et d'étude du génome, Département de génétique animale, Institut national de la recherche agronomique, Commissariat à l'énergie atomique, Jouy-en-Josas Cedex, France


© INRA, EDP Sciences 2000