The porcine Major Histocompatibility Complex and related paralogous regions: a review
© INRA, EDP Sciences 2000
Received: 18 November 1999
Accepted: 17 January 2000
Published: 15 March 2000
The physical alignment of the entire region of the pig major histocompatibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced. Over one hundred genes have been characterised, including the classical class I and class I-related genes, as well as the class II gene families. These results in swine provide new evidence for the striking conservation during the evolution of a general MHC framework, and are consistent with the location of the class I genes on segments referred to as permissive places within the MHC class I region. Recent results confirm the involvement of the SLA region in numerous quantitative traits.
(To access the full article, please see PDF)