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Genetics Selection Evolution

Open Access

Hepatic lipogenesis gene expression in two experimental egg-laying lines divergently selected on residual food consumption

  • Sandrine Lagarrigue1,
  • Stéphanie Daval1,
  • André Bordas2 and
  • Madeleine Douaire1Email author
Genetics Selection Evolution200032:205

Received: 13 September 1999

Accepted: 6 December 1999

Published: 15 March 2000


Two Rhode Island Red egg-laying lines have been divergently selected on residual food intake (low intake R- line, high intake R+ line) for 19 generations. In addition to direct response, correlated responses have altered several other traits such as carcass adiposity and lipid contents of several tissues, the R+ animals being leaner than the R- ones. In a search for the biological origin of the differences observed in fat deposit, the hepatic mRNA amounts of genes involved in lipid metabolism were investigated. No difference was found between lines for mRNA levels of ATP citrate-lyase, acetyl-CoA carboxylase, fatty acid synthase, malic enzyme and CCAAT/enhancer binding protein α, a transcription factor acting on several lipogenesis genes. The genes coding for stearoyl-CoA desaturase and apolipoprotein A1 displayed significantly lower mRNA levels in the R+ cockerels compared to the R-. All together these mRNA levels explained 40% of the overall variability of abdominal adipose tissue weight, suggesting an important role of both genes in the fatness variability.


laying fowlfood efficiencyfatnessmRNAliver

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Authors’ Affiliations

Laboratoire de génétique animale, Institut national de la recherche agronomique, École nationale supérieure agronomique de Rennes, Rennes Cedex, France
Laboratoire de génétique factorielle, Institut national de la recherche agronomique, Jouy-en-Josas Cedex, France


© INRA, EDP Sciences 2000