Open Access

A sampling algorithm for segregation analysis

Genetics Selection Evolution200133:587

https://doi.org/10.1186/1297-9686-33-6-587

Received: 27 June 2000

Accepted: 12 June 2001

Published: 15 November 2001

Abstract

Methods for detecting Quantitative Trait Loci (QTL) without markers have generally used iterative peeling algorithms for determining genotype probabilities. These algorithms have considerable shortcomings in complex pedigrees. A Monte Carlo Markov chain (MCMC) method which samples the pedigree of the whole population jointly is described. Simultaneous sampling of the pedigree was achieved by sampling descent graphs using the Metropolis-Hastings algorithm. A descent graph describes the inheritance state of each allele and provides pedigrees guaranteed to be consistent with Mendelian sampling. Sampling descent graphs overcomes most, if not all, of the limitations incurred by iterative peeling algorithms. The algorithm was able to find the QTL in most of the simulated populations. However, when the QTL was not modeled or found then its effect was ascribed to the polygenic component. No QTL were detected when they were not simulated.

Keywords

descent graphsMonte Carlo Markov chainquantitative trait lociMetropolis-Hastings

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Authors’ Affiliations

(1)
Animal Genetics and Breeding Unit (A joint institute of NSW Agriculture and the University of New England), University of New England

Copyright

© INRA, EDP Sciences 2001

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