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A note on QTL detecting for censored traits

Genetics Selection Evolution volume 38, Article number: 221 (2006) Cite this article

Abstract

Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and efficient approach to QTL detecting for censored traits with the Cox PH model without estimating the baseline hazard function which is "nuisance".

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  1. Department of Statistics, Columbia University, New York, NY, 10027, USA

    Yixin Fang

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  1. Yixin Fang
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Correspondence to Yixin Fang.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fang, Y. A note on QTL detecting for censored traits. Genet Sel Evol 38, 221 (2006). https://doi.org/10.1186/1297-9686-38-2-221

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  • DOI: https://doi.org/10.1186/1297-9686-38-2-221

Keywords

Genetics Selection Evolution

ISSN: 1297-9686