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  • Methodology
  • Open Access

A note on QTL detecting for censored traits

Genetics Selection Evolution200638:221

https://doi.org/10.1186/1297-9686-38-2-221

Received: 9 August 2005

Accepted: 6 October 2005

Published: 24 February 2006

Abstract

Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and efficient approach to QTL detecting for censored traits with the Cox PH model without estimating the baseline hazard function which is "nuisance".

Keywords

QTL detectingcensored traitinterval mapping

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Authors’ Affiliations

(1)
Department of Statistics, Columbia University, New York, USA

Copyright

© INRA, EDP Sciences 2006

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