Open Access

A meta-analytic assessment of a Thyroglobulin marker for marbling in beef cattle

  • Ian A. Wood1Email author,
  • Gerhard Moser2,
  • Daniel L. Burrell1,
  • Kerrie L. Mengersen1 and
  • D. Jay S. Hetzel2
Genetics Selection Evolution200638:479

https://doi.org/10.1186/1297-9686-38-5-479

Received: 27 September 2005

Accepted: 20 April 2006

Published: 6 September 2006

Abstract

A meta-analysis was undertaken reporting on the association between a polymorphism in the Thyroglobulin gene (TG5) and marbling in beef cattle. A Bayesian hierarchical model was adopted, with alternative representations assessed through sensitivity analysis. Based on the overall posterior means and posterior probabilities, there is substantial support for an additive association between the TG5 marker and marbling. The marker effect was also assessed across various breed groups, with each group displaying a high probability of positive association between the T allele and marbling. The WinBUGS program code used to simulate the model is included as an Appendix available online at http://www.edpsciences.org/gse.

Keywords

Bayesian hierarchical model meta-analysis association studies TG5 marker beef marbling

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Authors’ Affiliations

(1)
School of Mathematical Sciences, Queensland University of Technology
(2)
Genetic Solutions Pty. Ltd

Copyright

© INRA, EDP Sciences 2006

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