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Genetics Selection Evolution

Open Access

NNAT and DIRAS3 genes are paternally expressed in pigs

  • Huan-Chen Cheng1,
  • Feng-Wei Zhang1,
  • Chang-Yan Deng1Email author,
  • Cao-De Jiang2,
  • Yuan-Zhu Xiong1,
  • Feng-E Li1 and
  • Ming-Gang Lei1
Genetics Selection Evolution200739:599

https://doi.org/10.1186/1297-9686-39-5-599

Received: 24 December 2006

Accepted: 25 April 2007

Published: 27 September 2007

Abstract

Although expression and epigenetic differences of imprinted genes have been extensively characterised in man and the mouse, little is known on livestock species. In this study, the polymorphism-based approach was used to detect the imprinting status of NNAT and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F1 hybrids. The results show that both genes were paternally expressed in all the tested tissues (heart, liver, spleen, lung, kidney, stomach, small intestine, skeletal muscle, fat, uterus, ovary and pituitary). In addition, the NNAT gene had two transcripts in all tested tissues, which is consistent with its counterpart in man and cattle.

Keywords

pig NNAT DIRAS3 imprintingpaternally expressed

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Authors’ Affiliations

(1)
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agriculture University, Wuhan, PR China
(2)
Department of Bio-engineering, College of Animal Sciences, Southwest University, Chongqing, PR China

Copyright

© INRA, EDP Sciences 2007

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