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Impact of strong selection for the PrP major gene on genetic variability of four French sheep breeds (Open Access publication)

  • 1Email author,
  • 2,
  • 3,
  • 4,
  • 5,
  • 6, 7,
  • 1,
  • 1,
  • 5,
  • 3,
  • 1 and
  • 6, 7
Genetics Selection Evolution200840:663

https://doi.org/10.1186/1297-9686-40-6-663

Received: 7 February 2008

Accepted: 22 August 2008

Published: 15 November 2008

Abstract

Effective selection on the PrP gene has been implemented since October 2001 in all French sheep breeds. After four years, the ARR "resistant" allele frequency increased by about 35% in young males. The aim of this study was to evaluate the impact of this strong selection on genetic variability. It is focussed on four French sheep breeds and based on the comparison of two groups of 94 animals within each breed: the first group of animals was born before the selection began, and the second, 3–4 years later. Genetic variability was assessed using genealogical and molecular data (29 microsatellite markers). The expected loss of genetic variability on the PrP gene was confirmed. Moreover, among the five markers located in the PrP region, only the three closest ones were affected. The evolution of the number of alleles, heterozygote deficiency within population, expected heterozygosity and the Reynolds distances agreed with the criteria from pedigree and pointed out that neutral genetic variability was not much affected. This trend depended on breed, i.e. on their initial states (population size, PrP frequencies) and on the selection strategies for improving scrapie resistance while carrying out selection for production traits.

Keywords

  • genetic variability
  • scrapie resistance
  • molecular marker
  • pedigree
  • sheep

(To access the full article, please see PDF)

Authors’ Affiliations

(1)
INRA, UR631 Station d'Amélioration génétique des animaux, Castanet-Tolosan, France
(2)
Institut de l'É levage, Département de Génétique, Jouy-en-Josas, France
(3)
INRA, UR339 Laboratoire de génétique biochimique et cytogénétique, Jouy-en-Josas, France
(4)
INRA, UR337 Station de génétique quantitative appliquée, Jouy-en-Josas, France
(5)
LABOGENA, Jouy-en-Josas, France
(6)
INRA, UMR1236 Génétique et diversité animales, Jouy-en-Josas, France
(7)
AgroParisTech, UMR1236 Génétique et diversité animales, Paris 05, France

Copyright

© INRA, EDP Sciences 2008

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