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Table 1 Risk of AS and CS according to genotypes

From: Quantitative estimation of genetic risk for atypical scrapie in French sheep and potential consequences of the current breeding programme for resistance to scrapie on the risk of atypical scrapie

  

AS

CS

Genotype

No controls*

No cases

OR(CI 95%)

Prevalence ‰ (ci 95%)§

No cases

OR (CI 95%)

ALRR-ALRR

772

45

12.7 (2.9-55.1)**

0.60 (0.45 - 0.78)

0

NA††

ALRR-ALHQ

70

24

75.2 (16.6-340.6) **

3.56 (2.21 - 5.59)

0

NA††

ALRR-AFRQ

147.4

54

82.9 (13.6-506.5)**

3.77 (2.80 - 5.02)

0

NA††

ALRR-ALRQ

1003.4

10

2.2 (0.5-10.0)

0.11 (0.06 - 0.19)

2

0.0 (0.0-0.1)

ALRR-ALRH

126.1

3

5.3 (0.6-46.4)

0.30 (0.09 - 0.72)

0

NA††

ALRR-VLRQ

188

0

NA††

0 (0.0 - 0.19)

16

0.5 (0.2-1.0)‡‡

ALHQ-ALHQ

3

6

454.8 (61.2-3381.4)**

19.47 (5.61 - 75.07)

1

1.4 (0.1-15.7)

AFRQ-ALHQ

9.8

11

253.5 (29.0-2213.8)**

11.45 (5.16 - 27.48)

0

NA††

ALHQ-ALRQ

65.9

13

41.6 (9.0-192.2)**

2.11 (1.10 - 3.51)

1

0.1 (0.0-0.8)‡‡

ALHQ-ALRH

8.4

2

54.1 (4.2-689.3) ‡‡

3.03 (0.58 - 10.01)

0

NA††

ALHQ-VLRQ

4

1

51.1 (3.7-709.0)‡‡

3.55 (0.44 - 18.14)

2

2.0 (0.3-12.1)

AFRQ-AFRQ

11.6

28

724.3 (49.4-10625.1)**

23.56 (12.65 - 47.08)

2

1.5 (0.1-22.1)

AFRQ-ALRQ

126.4

43

76.9 (13.5-438.7)

3.50 (2.44 - 4.74)

20

1.0 (0.3-3.2)

ALRQ-ALRQ

445.5

2

Baseline category

0.06 (0.01 - 0.17)

69

Baseline

ALRQ-ALRH

106.7

0

NA††

0 (0 - 0.37)

8

0.5 (0.1-1.8)

AFRQ-ALRH

16.5

1

15.7 (0.7-335.4)

1.01 (0.15 - 3.61)

2

1.0 (0.1-12.2)

ALRH-ALRH

9.7

1

33.8 (1.1-1008.5) ‡‡

1.73 (0.29 - 6.61)

1

1.0 (0.0-24.6)

AFRQ-VLRQ

21.5

3

31.7 (3.4-293.4)

1.71 (0.50 - 4.64)

6

1.7 (0.3-8.2)

ALRQ-VLRQ

147.1

0

NA††

0 (0.00 - 0.26)

85

3.6 (2.3-5.6)**

ALRH-VLRQ

18.4

1

12.7 (0.8-212.6)

0.91 (0.13 - 3.27)

9

3.2 (0.6-17.1)

VLRQ-VLRQ

16

0

NA††

0.45 (0.02 - 2.48)

21

7.8 (3.3-18.1)

General population

   

0.76 (0.69 - 0.83)

  

Healthy slaughter

  

Baseline category

  

Baseline

Fallen stock

  

1.0 (0.7-1.3)

  

6.44 (4.43-9.37)**

2-4 DI

  

Baseline category

  

Baseline

5-7 DI§§

  

1.6 (0.4-6.5)

  

1.04 (0.43-2.49)

8 DI***

  

3.0 (0.8-11.4)

  

1.07 (0.46-2.50)

  1. * Mean value for the 1,000 bootstraps
  2. Odds Ratio
  3. 95% confidence interval
  4. § 95% credibility interval
  5. ** p-value < 0.001
  6. †† Not available: no individual with that genotype
  7. ‡‡ p-value ≤ 0.05
  8. §§ 5-7 definitive incisors: 2- to 4-year old animals
  9. *** 8 definitive incisors: animals of 4 years old and more