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Table 6 Frequencies of estimated probabilities of being a carrier

From: Reconstructing CNV genotypes using segregation analysis: combining pedigree information with CNV assay

Status

Half-sibs

P < 0.001

P < 0.01

P < 0.05

P > 0.95

P > 0.99

P > 0.999

carrier

1

0.00

0.01

0.04

0.48

0.48

0.48

carrier

2

0.00

0.01

0.04

0.48

0.48

0.48

carrier

4

0.00

0.01

0.04

0.50

0.50

0.50

carrier

8

0.00

0.00

0.02

0.58

0.54

0.53

carrier

16

0.00

0.00

0.01

0.66

0.62

0.57

carrier

32

0.00

0.00

0.01

0.72

0.70

0.66

non-carrier

1

0.20

0.46

0.69

0.00

0.00

0.00

non-carrier

2

0.28

0.47

0.69

0.00

0.00

0.00

non-carrier

4

0.35

0.57

0.73

0.00

0.00

0.00

non-carrier

8

0.46

0.68

0.79

0.00

0.00

0.00

non-carrier

16

0.63

0.75

0.81

0.00

0.00

0.00

non-carrier

32

0.72

0.78

0.82

0.00

0.00

0.00

  1. For progeny, given actual status (carrier or non-carrier) and number of half-sibs in family; the assay CV simulated and CV used in the analysis were both 3% and the progeny and sire in each family were assayed