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Table 5 Molecular and cellular functions affected by inoculation and cell culture

From: Comparative expression profiling of E. coli and S. aureus inoculated primary mammary gland cells sampled from cows with different genetic predispositions for somatic cell score

 

E. coli inoculated

Un-inoculated control

Top 5 categories of molecular and cellular functions

SCS-BTA18-Q

SCS-BTA18-q

SCS-BTA18-Q

SCS-BTA18-q

E. coli inoculated

SCS-BTA18-Q cells

p-values

Genes

p-values

Genes

p-values

Genes

p-values

Genes

Cell cycle

2,98E-18

120

2,26E-25

164

1,98E-04

25

1,19E-02

2

Cellular growth and proliferation

1,10E-10

215

2,56E-11

279

1,28E-02

10

3,28E-02

2

Cellular assembly and organization

9,30E-10

59

2,14E-10

70

1,28E-02

12

1,33E-03

2

DNA replication, recombination and repair

9,30E-10

96

2,14E-10

154

3,18E-02

5

---

---

RNA-post-transcriptional modification

3,70E-06

39

9,50E-06

42

1,58E-03

11

4,56E-02

1

 

E. coli inoculated

Un-inoculated control

Top 5 categories of molecular and cellular functions

SCS-BTA18-Q

SCS-BTA18-q

SCS-BTA18-Q

SCS-BTA18-q

E. coli inoculated

SCS-BTA18-q cells

p-values

Genes

p-values

Genes

p-values

Genes

p-values

Genes

Cell cycle

2,98E-18

120

2,26E-25

164

1,98E-04

25

1,19E-02

2

Cellular growth and proliferation

1,10E-10

215

2,56E-11

279

1,28E-02

10

3,28E-02

2

Cellular assembly and organization

9,30E-10

59

2,14E-10

70

1,28E-02

12

1,33E-03

2

DNA replication, recombination and repair

9,30E-10

96

2,14E-10

154

3,18E-02

5

---

---

Cell death

7,33E-06

153

2,27E-10

227

6,73E-03

8

---

---

 

S. aureus inoculated

E. coli inoculated

Un-inoculated control

Top 5 categories of molecular and cellular functions

SCS-BTA18-Q

SCS-BTA18-Q

SCS-BTA18-q

SCS-BTA18-Q

S. aureus inoculated

SCS-BTA18-Q cells

p-values

Genes

p-values

Genes

p-values

Genes

p-values

Genes

Cellular assembly and organization

6,54E-05

14

9,30E-10

59

2,14E-10

70

1,28E-02

12

Cell death

2,03E-04

33

7,33E-06

153

2,27E-10

227

6,73E-03

8

DNA replication, recombination and repair

2,61E-04

20

9,30E-10

96

2,14E-10

154

3,18E-02

5

Nucleic acid metabolism

2,61E-04

9

3,54E-03

4

4,61E-03

14

7,60E-04

6

Small molecule biochemistry

2,61E-04

18

7,60E-05

53

3,80E-03

26

2,56E-04

19

  1. Top five molecular and cellular functions affected between time points 1 h and 24 h in SCS-BTA18-Q and SCS-BTA18-q cells by inoculation; the molecular and cellular functional category, p-values and the number of involved genes are shown for E. coli inoculated SCS-BTA18-Q and SCS-BTA18-q cells and S. aureus inoculated SCS-BTA18-Q cells, as well as for the control cells; the categories are ranked by p-values of the SCS-BTA18-Q and SCS-BTA18-q cells, respectively, and related p-values and the number of involved genes are shown for the alternative QTL allele and the un-inoculated control cells; for S. aureus inoculated SCS-BTA18-q cells the number of significantly differentially expressed genes was to low to perform a reliable investigation of associated molecular and cellular functions; hence, for SCS-BTA18-Q cells additionally the related p-values and the number of involved genes are shown for E. coli inoculated cells and for un-inoculated SCS-BTA18-Q control cells.
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Genetics Selection Evolution

ISSN: 1297-9686