Comparative expression profiling of E. coli and S. aureus inoculated primary mammary gland cells sampled from cows with different genetic predispositions for somatic cell score

Table 6 Gene table canonical pathways

QTL allele	Pathogen	Canonical pathway	Genes
SCS-BTA18-Q	E.coli	Dendritic cell maturation	HLA-DMA, IL1A, ICAM1, RELB, NFKBIE, IL1F6, HLA-DQA1, HLA-DRB1, LTB, HLA-DMB, IKBKE, IL6, NFKB2, NFKB1, TLR2, HLA-DQB1, NFKBIA, HLA-A, CD40, IL1RN, HLA-DRA, COL10A1, IL1B, NFKBIB
		Acute phase response signaling	IL1A, SAA3P, APOA1, RRAS, NFKBIE, C1S, IL1F6, IKBKE, IL6, NFKB2, NFKB1, HMOX2, C1R, SOD2, NFKBIA, IL1RN, CFB, IL1B, NFKBIB
SCS-BTA18-q	E.coli	Dendritic cell maturation	HLA-DMA, IL1A, ICAM1, NFKBIE, IL1F6, HLA-DRB1, LTB, IKBKE, HLA-DMB, IL6, NFKB2, NFKB1, TLR2, HLA-DQB1, NFKBIA, HLA-A, CD40, IL1RN, HLA-DRA, IL1B
		Acute phase response signaling	IL1A, SAA3P, C3, NFKBIE, C1S, SOCS2, IL1F6, IKBKE, IL6, NFKB2, NFKB1, HMOX2, C1R, HMOX1, SOD2, NFKBIA, IL1RN, CFB, IL1B, C2
SCS-BTA18-Q	S. aureus	Dendritic cell maturation	IL1A, ICAM1, RELB, NFKBIE, HLA-DQA1, PIK3R5, HLA-DRB1, LTB, IKBKE, IL6, NFKB2, NFKB1, TLR2, HLA-DQB1, NFKBIA, CD40, IL1RN, HLA-DRA, IL1B
		Acute phase response signaling	SOCS1, IL1A, SAA3P, APOA1, NFKBIE, IKBKE, NFKB2, IL6, NFKB1, HMOX2, NFKBIA, SOD2, IL1RN, CFB, IL1B
SCS-BTA18-q	S. aureus	Acute phase response signaling	C1R, HMOX1, IL1A, NFKBIA, C1S, IL1F6, IL6, FGG, CRABP1
		Dendritic cell maturation	HLA-DQB1, IL1A, NFKBIA, IL1F6, CD83, IL6

Summary of genes associated with Ingenuity canonical pathways 'dendritic cell maturation' and 'acute phase response signaling' in S. aureus and E. coli inoculated SCS-BTA18-Q and SCS-BTA18-q cells, respectively.

ISSN: 1297-9686