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Table 6 Gene table canonical pathways

From: Comparative expression profiling of E. coli and S. aureus inoculated primary mammary gland cells sampled from cows with different genetic predispositions for somatic cell score

QTL allele Pathogen Canonical pathway Genes
SCS-BTA18-Q E.coli Dendritic cell maturation HLA-DMA, IL1A, ICAM1, RELB, NFKBIE, IL1F6, HLA-DQA1, HLA-DRB1, LTB, HLA-DMB, IKBKE, IL6, NFKB2, NFKB1, TLR2, HLA-DQB1, NFKBIA, HLA-A, CD40, IL1RN, HLA-DRA, COL10A1, IL1B, NFKBIB
   Acute phase response signaling IL1A, SAA3P, APOA1, RRAS, NFKBIE, C1S, IL1F6, IKBKE, IL6, NFKB2, NFKB1, HMOX2, C1R, SOD2, NFKBIA, IL1RN, CFB, IL1B, NFKBIB
SCS-BTA18-q E.coli Dendritic cell maturation HLA-DMA, IL1A, ICAM1, NFKBIE, IL1F6, HLA-DRB1, LTB, IKBKE, HLA-DMB, IL6, NFKB2, NFKB1, TLR2, HLA-DQB1, NFKBIA, HLA-A, CD40, IL1RN, HLA-DRA, IL1B
   Acute phase response signaling IL1A, SAA3P, C3, NFKBIE, C1S, SOCS2, IL1F6, IKBKE, IL6, NFKB2, NFKB1, HMOX2, C1R, HMOX1, SOD2, NFKBIA, IL1RN, CFB, IL1B, C2
SCS-BTA18-Q S. aureus Dendritic cell maturation IL1A, ICAM1, RELB, NFKBIE, HLA-DQA1, PIK3R5, HLA-DRB1, LTB, IKBKE, IL6, NFKB2, NFKB1, TLR2, HLA-DQB1, NFKBIA, CD40, IL1RN, HLA-DRA, IL1B
   Acute phase response signaling SOCS1, IL1A, SAA3P, APOA1, NFKBIE, IKBKE, NFKB2, IL6, NFKB1, HMOX2, NFKBIA, SOD2, IL1RN, CFB, IL1B
SCS-BTA18-q S. aureus Acute phase response signaling C1R, HMOX1, IL1A, NFKBIA, C1S, IL1F6, IL6, FGG, CRABP1
   Dendritic cell maturation HLA-DQB1, IL1A, NFKBIA, IL1F6, CD83, IL6
  1. Summary of genes associated with Ingenuity canonical pathways 'dendritic cell maturation' and 'acute phase response signaling' in S. aureus and E. coli inoculated SCS-BTA18-Q and SCS-BTA18-q cells, respectively.