Figure 1

Variation between SNPs and effect of adjusting for uncertainty. Intensity is plotted against allelic proportion p (see Equation 1) for all individuals for four selected SNPs, using both the unadjusted areas (left hand side) and areas adjusted for the uncertainty associated with the area estimate as provided by the genotyping provider (right hand side); intensities are estimated as Euclidean distances from the origin to the data points in Cartesian coordinates; for the adjusted areas, the mean and standard deviation of the allelic proportion estimates (p) are provided.