Figure 2
From: Two recessive mutations in FGF5 are associated with the long-hair phenotype in donkeys
Wild type and mutant FGF5 proteins. (A) Alignment of the FGF5 amino-acid sequence predicted from the equine wild type allele (Wt-FGF5, [Ensembl:ENSECAT00000016512]) and the c.433_434delAT mutant Poitou allele (Po-FGF5). The signal peptide is indicated in bold characters. The secondary structure predicted by the Phyre2 program is represented by the arrows below the Wt-FGF5 sequence. Arrows with numbers represent the 12 β-strands. The predicted N-ter α-helix is indicated. The frameshift produced by the c.433_434delAT deletion is framed. A star indicates the location of the stop codon produced by the c.245G > A nonsense mutation. (B) 3D models built using the Phyre server represent the horse wild type Wt-FGF5 (left) and the donkey c.433_434delAT Poitou Po-FGF5 (right) proteins; the α-helix is highlighted in blue and the β strands are depicted by arrows.