Table 3 List of candidate genes identified based on control chart outliers values
BTA | Gene symbol | Gene name | Biological function |
|---|---|---|---|
1 | ACAD11 | acyl-CoA dehydrogenase family, member 11 | lipid metabolism |
| Â | CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | cartilage morphogenesis |
| Â | SOD1 | superoxide dismutase 1, soluble | oxidative stress |
2 | PROC | protein C (inactivator of coagulation factors Va and VIIIa) | immune response |
3 | ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 | lipid metabolism |
4 | ABCB8 | ATP-binding cassette, sub-family B (MDR/TAP), member 8 | transport of heme |
| Â | ABCF2 | ATP-binding cassette, sub-family F (GCN20), member 2 | transport of heme |
| Â | CHN2 | chimerin 2 | smooth muscle cell proliferation |
| Â | CHPF2 | chondroitin polymerizing factor 2 | cartilage biosynthesis |
| Â | TWIST1 | twist family bHLH transcription factor 1 | bone and muscle development |
| Â | NRF1 | nuclear respiratory factor 1 | heme biosynthesis/transport |
| Â | ACCN3 | acid-sensing (proton-gated) ion channel 3 | Sensory neuron physiology pain induced by acidosis |
| Â | SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | heme biosynthesis/transport |
5 | CACNG2 | calcium channel, voltage-dependent, gamma subunit 2 | behavioural disorders |
| Â | CALCOCO1 | calcium binding and coiled-coil domain 1 | cell growth |
| Â | CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | cartilage biosynthesis |
| Â | RARG | retinoic acid receptor, gamma | skeletal development |
| Â | PVALB | parvalbumin | muscle relaxation |
| Â | APAF1 | apoptotic peptidase activating factor 1 | apoptosis |
| Â | SOAT2 | sterol O-acyltransferase 2 | cholesterol metabolism |
| Â | KRTs | keratins | epithelia development |
| Â | AMHR2 | Anti-Mullerian hormone receptor, type II | male sex differentiation |
6 | GBA3 | glucosidase, beta, acid 3 (gene/pseudogene) | flavonoids metabolism |
| Â | HADH | hydroxyacyl-CoA dehydrogenase | lipid metabolism |
| Â | ZAR1 | zygote arrest 1 | reproduction |
7 | LECT2 | leukocyte cell-derived chemotaxin 2 | cartilage/bone differentiation |
| Â | TGFBI | transforming growth factor, beta-induced, 68kDa | cartilage/bone development |
8 | ALDOB | aldolase B, fructose-bisphosphate | carbohydrates metabolism |
| Â | LOXL2 | lysyl oxidase-like 2 | biogenesis of connective |
9 | CTGF | connective tissue growth factor | connective morphogenesis |
| Â | VNN2 | vanin 2 | stress oxidative response |
11 | PROKR1 | prokineticin receptor 1 | Ca+2 mobilization |
| Â | WDR92 | WD repeat domain 92 | apoptosis modulator |
13 | UQCC | ubiquinol-cytochrome c reductase complex assembly factor 1 | skeletal development |
| Â | MYL9 | myosin, light chain 9, regulatory | muscle metabolism |
| Â | DEFBs | defensin beta | immune response |
| Â | GDF5 | growth differentiation factor 5 | skeletal development |
| Â | ACSS2 | acyl-CoA synthetase short-chain family member 2 | lipid metabolism |
| Â | ADIG | adipogenin | adipocyte development |
| Â | PROCR | protein C receptor, endothelial | immune response |
| Â | BPIFB2 BPIF 3 BPIF6 | BPI fold containing family B, members 2, 3 and 6 | innate immune response |
14 | FBXO32 | F-box protein 32 | muscular diseases |
| Â | GPT | glutamic-pyruvate transaminase (alanine aminotransferase) | liver gluconeogenesis |
15 | DGAT2 | diacylglycerol O-acyltransferase 2 | lipid metabolism |
| Â | TUB | tubby bipartite transcription factor | obesity |
| Â | HBs | haemoglobins | oxygen binding/transport |
16 | ACBD3 | acyl-CoA binding domain containing 3 | reproduction |
| Â | DHRS3 | dehydrogenase/reductase (SDR family) member 3 | steroids metabolism |
| Â | PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | connective synthesis |
17 | ACADS | acyl-CoA dehydrogenase, C-2 to C-3 short chain | lipid metabolism |
18 | ACSF3 | acyl-CoA synthase family member 3 | lipid metabolism |
| Â | MVD | mevalonate (diphospho) decarboxylase | cholesterol biosynthesis |
19 | SPEM1 | spermatid maturation 1 | reproduction |
| Â | SHBG | sex hormone-binding globulin | steroids metabolism |
| Â | DNAH2 | dynein, axonemal, heavy chain2 | sperm motility |
| Â | GAA | glucosidase, alpha; acid | carbohydrates metabolism |
| Â | ATP1B2 | ATPase, Na+/K+ transporting, beta 2 polypeptide | osmoregulation |
| Â | ACADVL | acyl-CoA dehydrogenase, very long chain | lipid metabolism |
| Â | ALOXs | arachidonate-lipoxygenases | lipid metabolism |
| Â | MYHs | myosin, heavy chain skeletal muscle | muscle biology |
| Â | CARD14 | caspase recruitment domain family, member 14 | apoptosis |
| Â | EFNB3 | ephrin B3 | brain development |
| Â | ATP1B2 | ATPase, Na/K transporting beta 2 polypeptide | neurite outgrowth |
22 | PDHB | pyruvate dehydrogenase (lipoamide) beta | tricarboxylic acid cycle |
| Â | FLNB | filamin B, beta | cartilage/bone morphogenesis |
| Â | TLR9 | toll-like receptor 9 | immune response |
| Â | OXTR | oxytocin receptor | parturition |
| Â | CAV3 | caveolin 3 | muscle biology |
| Â | ALAS1 | aminolevulinate, delta-, synthase 1 | biosynthesis of heme |
| Â | ACOX2 | acyl-CoA oxidase 2, branched chain | lipid metabolism |
23 | MLN | motilin | control of peristalsis |
| Â | GLO1 | glyoxalase | osteoclastogenesis |
24 | DLGAP1 | disc, large (Drosophila) homolog-associated protein 1 | postsynaptic scaffold in neuronal cell |
25 | CARD11 | caspase recruitment domain family, member 11 | apoptosis |
| Â | CALN1 | calneuron 1 | memory and learning |
26 | LOXL4 | lysyl oxidase-like 4 | biogenesis of connective tissue |
| Â | CRTAC1 | cartilage acidic protein 1 | cartilage production |
28 | CXCL12 | chemokine (C-X-C motif) ligand 12 | immune response |