Fig. 2

Topological clustering of MHC-B haplotypes based on SNP identity. The network depicts a neighbor-joining topology computed from pair-wise uncorrected fractional dissimilarity. Clusters are based on (1) the median pairwise patristic distance (MPPD) between each node with a similarity of 90 % or more (colored clusters) and (2) bootstrap reliability greater than 70 % (colored clusters with solid lines). Haplotypes that met the first but not the second, criterion are indicated by dashed lines. Unique haplotypes are indicated by stippled lines. Serological information (MHC-B type) is provided when available. The outermost circle of letters (A to V) refers to a specific cluster and is used throughout the text