Table 2 Top ten biological pathways associated with bTB susceptibility based on the results of the single-SNP regression analysis applied to GWAS
Pathway name | Corrected P value | Source | Genes |
|---|---|---|---|
Antigen processing and presentation | 0.0011 | PID BIOCARTA | BT.91437, PSMB8, PSMB9, TAP1 |
Arf1 pathway | 0.0011 | PID NCI | AP2A1, AP2M1, CD4, CYTH2, KDELR1 |
Validated targets of C-MYC transcriptional activation | 0.0115 | PID NCI | BAX, BT.19231, EIF4A1, NME2, PDCD10, RUVBL2, TP53 |
Nef Mediated CD4 Down-regulation | 0.0145 | REACTOME | AP2A1, AP2M1, CD4 |
ABC transporters | 0.0285 | KEGG | ABCC3, BT.104466, BT.87418, BT.91437, TAP1 |
Classical Kir channels | 0.0321 | REACTOME | BT.62324, KCNJ12 |
Antigen processing and presentation | 0.0719 | KEGG | BOLA-DMA, BT.91437, CD4, TAP1 |
ER-Phagosome pathway | 0.0719 | REACTOME | BT.91437, PSMB8, PSMB9, PSMD2, TAP1 |
Nef Mediated CD8 Down-regulation | 0.0786 | REACTOME | AP2A1, AP2M1 |
Tnf/stress related signalling | 0.0838 | PID BIOCARTA | ATF1, MAP2K3, TANK |