Table 4 Top ten biological pathways associated with bTB susceptibility using results from the Bayesian approach applied to GWAS
Pathway name | Corrected P value | Source | Genes |
|---|---|---|---|
Signalling events mediated by HDAC Class II | 2.66 × 10−14 | PID NCI | BCL6, BCOR, GNB1, GNG2, HDAC4, HDAC7, HSP90AA1, NCOR2, RAN, YWHAB, YWHAE |
Cell cycle | 4.63 × 10−9 | KEGG | EP300, GADD45A, GADD45B, GADD45G, HDAC2, MDM2, SFN, YWHAB, YWHAE, YWHAG, YWHAQ, YWHAZ |
Insulin receptor signalling | 9.85 × 10−9 | INOH | PPP2R1A, PPP2R1B, PRKAA1, PRKAA2, SFN, YWHAB, YWHAE, YWHAG, YWHAQ, YWHAZ |
Glucocorticoid receptor regulatory network | 1.05 × 10−8 | PID NCI | BT.26220, BT.55996, BT.60919, EGR1, HDAC2, HSP90AA1, MDM2, NCOA2, SFN |
Mechanism of gene regulation by peroxisome proliferators via ppara | 1.18 × 10−8 | PID BIOCARTA | BT.26220, BT.55996, BT.78456, EP300, HSP90AA1, NCOR1, NCOR2, NR0B2 |
Androgen receptor | 2.88 × 10−8 | NETPATH | BT.55996, BT.61976, EP300, HDAC7, HSP90AA1, MDM2, NCOA2, NCOR1, NCOR2, NR0B2, RAN, RANBP9 |
Leptin | 3.72 × 10−8 | NETPATH | BT.26220, BT.55996, BT.60919, BT.61976, EP300, IKBKG, ITGB5, LIMK1, PRKAA1, PRKAA2 |
Notch | 4.10 × 10−8 | NETPATH | APP, BT.26220, BT.60919, BT.61976, EP300, HDAC2, NCOR1, NCOR2, SPEN |
Pathways in cancer | 4.36 × 10−8 | KEGG | BT.25770, BT.26220, BT.56113, BT.60919, BT.78456, EP300, HDAC2, HSP90AA1, IKBKG, MDM2, PPARD, RAC2, RHOA, RXRB, RXRG |
TNF alpha | 7.31 × 10−8 | NETPATH | BT.26220, BT.60919, BT.61976, BT.78456, EP300, GLUL, HDAC2, HSP90AA1, IKBKG, YWHAB, YWHAE, YWHAG, YWHAQ, YWHAZ |