Table 1 Number of variants identified per gene and predicted effect on protein sequence
Gene name | High impact | Moderate impact | Low impact | Total | ||
|---|---|---|---|---|---|---|
Stop gain | Mdel | Mtol | Synonymous | Start gain | ||
TLR1 | 4 | 7 | 19 | 22 | 2 | 54 |
TLR2 | 0 | 5 | 11 | 18 | 2 | 36 |
TLR3 | 0 | 5 | 5 | 7 | 0 | 17 |
TLR4 | 0 | 0 | 1 | 7 | 0 | 8 |
TLR5 | 0 | 8 | 9 | 24 | 0 | 41 |
TLR6 | 0 | 5 | 21 | 13 | 1 | 40 |
TLR7 | 0 | 0 | 4 | 15 | 1 | 20 |
TLR8 | 1 | 5 | 5 | 20 | 1 | 32 |
TLR9 | 0 | 3 | 5 | 12 | 0 | 20 |
TLR10 | 1 | 7 | 16 | 14 | 0 | 38 |
total | 6 | 45 | 96 | 152 | 7 | 306 |