Genome-wide association studies and genomic prediction of breeding values for calving performance and body conformation traits in Holstein cattle

Table 5 KEGG biological pathways enriched with the identified candidate genes for calving performance and body conformation traits

Pathway name	P-value	Gene name
Calving performance
Tight junction	0.016	MYH13, MYH14, PPP2R1A, PRKCG, MYH10
Oxytocin signaling	0.040	CACNG6, CACNG7, KCNJ14, PPP1R12C, PRKCG
MAPK signaling	0.065	CACNG6, FGF21, CACNG7, FGF6, FGF23, PRKCG
Body conformation
Glutamatergic synapse	0.013	SHANK1, CACNA1C, PLCB1, SLC17A7, ITPR2
MAPK signaling	0.017	FGF21, CACNA1C, FGF23, RRAS, LOC615727, RASGRF2, NTRK2
Aldosterone synthesis and secretion	0.026	ATF1, CACNA1C, PLCB1, ITPR2
Oxytocin signaling	0.035	OXT, CACNA1C, PLCB1, KCNJ14, ITPR2
Retrograde endocannabinoid signaling	0.047	CACNA1C, PLCB1, SLC17A7, ITPR2
Cholinergic synapse	0.059	CACNA1C, PLCB1, KCNJ14, ITPR2
Staphylococcus aureus infection	0.072	FCAR, C2, CFB
Dopaminergic synapse	0.077	CACNA1C, PLCB1, PPP2R1A, ITPR2
Long-term depression	0.082	PLCB1, PPP2R1A, ITPR2
Ribosome	0.090	RPS11, RPS9, RPL36, RPL13A
Long-term potentiation	0.096	CACNA1C, PLCB1, ITPR2
Renin secretion	0.099	CACNA1C, PLCB1, ITPR2

ISSN: 1297-9686