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Table 2 Differentially-methylated windows between the selection lines

From: Epigenetics and early domestication: differences in hypothalamic DNA methylation between red junglefowl divergently selected for high or low fear of humans

Chr

Window start (bp)

CpGs

logFC

Adjusted p value

Gene symbol

Gene description

1

121,257,001

4

− 1.33

9.52e − 02

AP1S2

Adaptor related protein complex 1 sigma 2 subunit [Source:HGNC Symbol;Acc:HGNC:560]

1

142,947,001

4

− 0.93

5.87e − 02

NALCN

Sodium leak channel, non-selective [Source:CGNC Symbol;Acc:12660]

1

174,158,001

7

− 0.90

9.52e − 02

  

1

188,959,001

7

1.40

5.14e − 02

DLG2

Discs, large homolog 2 (Drosophila) [Source:CGNC Symbol;Acc:12965]

1

192,474,001

5

1.35

3.27e − 07

CAPN5

Calpain 5 [Source:CGNC Symbol;Acc:479]

2

73,558,001

3

− 2.75

8.12e − 02

  

2

85,911,001

12

0.80

9.52e − 02

  

3

9,149,001

7

1.11

3.22e − 02

EHBP1

EH domain binding protein 1 [Source:CGNC Symbol;Acc:6763]

3

53,750,001

7

1.31

2.73e − 02

ARFGEF3

ARFGEF family member 3 [Source:CGNC Symbol;Acc:10361]

3

106,780,001

5

1.70

4.83e − 03

MTMR9

Myotubularin related protein 9 [Source:CGNC Symbol;Acc:12476]

4

27,239,001

3

− 0.98

9.24e − 02

  

5

30,875,001

3

− 0.80

3.22e − 02

  

5

57,981,001

7

1.12

7.28e − 02

C5h14orf166

Gallus gallus chromosome 5 open reading frame, mRNA. [Source:RefSeq mRNA;Acc:NM_205369]

5

58,733,001

12

0.99

7.79e − 02

  

11

16,608,001

16

− 1.29

5.91e − 02

  

14

5,936,001

11

− 0.83

8.12e − 02

  

15

6,629,001

22

1.13

3.22e − 02

USP30

Ubiquitin specific peptidase 30 [Source:CGNC Symbol;Acc:50370]

17

1,582,001

8

1.87

8.12e − 02

MRPL41

Mitochondrial ribosomal protein L41 [Source:CGNC Symbol;Acc:6639]

17

1,582,001

8

1.87

8.12e − 02

PNPLA7

Patatin-like phospholipase domain containing 7 [Source:CGNC Symbol;Acc:6632]

18

10,927,001

23

0.89

5.14e − 02

ARMC7

Armadillo repeat containing 7 [Source:CGNC Symbol;Acc:6023]

19

58,001

3

− 0.95

1.01e − 02

DDX25

DEAD-box helicase 25 [Source:HGNC Symbol;Acc:HGNC:18698]

20

11,544,001

11

1.15

3.22e − 02

  

23

3,692,001

5

1.38

7.28e − 02

GNL2

Guanine nucleotide binding protein-like 2 (nucleolar) [Source:CGNC Symbol;Acc:1398]

  1. Comparison between HFH and LFH red junglefowl individuals resulted in 22 differentially-methylated 1-kb windows at FDR-corrected p < 0.1. Of these, 13 aligned within genes or promoter regions of genes. The log fold changes (logFC) are based on the comparison between HFH and LFH birds, with HFH birds set as reference in the MEDIPS analysis