The impact of genome editing on the introduction of monogenic traits in livestock

Table 4 Population parameters after 20 generations of selection

Method	b ^a₂	Reduced response		Frequency^c	\(\overline{F}\) ^d	Number^e	Cumulative benefit^f
Method	b ^a₂	σ _A	Months^b	Frequency^c	\(\overline{F}\) ^d	Number^e	Dominant (%)	Recessive (%)
	0	0	0	0.01	0.058	0	1.9	0.0
GS	0.5	− 0.76	− 11.9	0.98	0.060	0	85.3	69.9
	1000	− 2.02	− 31.3	0.96	0.070	0	95.9	84.8
	0	+ 0.07	+ 1.05	1.00	0.058	22,118	89.6	74.0
GS + GE	0.5	− 0.11	− 1.7	1.00	0.060	7072	96.1	92.4
	1000	− 0.83	− 12.9	1.00	0.064	3912	97.6	94.8

^aIndex weight for the genotype of the monogenic trait
^bMonths of selection response lost for the polygenic trait in generation 20, compared to the genetic level of genomic selection (GS) with b₂ = 0
^cFrequency of the desired allele in generation 20
^dMean inbreeding coefficient in generation 20
^eCumulative number of zygotes edited over 20 generations
^fPercentage of animals, cumulative over the 20 generations, with the desired phenotype when the desired allele is either dominant or recessive

ISSN: 1297-9686