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Table 4 Population parameters after 20 generations of selection

From: The impact of genome editing on the introduction of monogenic traits in livestock

Method b a2 Reduced response Frequencyc \(\overline{F}\) d Numbere Cumulative benefitf
σ A Monthsb Dominant (%) Recessive (%)
  0 0 0 0.01 0.058 0 1.9 0.0
GS 0.5 − 0.76 − 11.9 0.98 0.060 0 85.3 69.9
  1000 − 2.02 − 31.3 0.96 0.070 0 95.9 84.8
  0 + 0.07 + 1.05 1.00 0.058 22,118 89.6 74.0
GS + GE 0.5 − 0.11 − 1.7 1.00 0.060 7072 96.1 92.4
  1000 − 0.83 − 12.9 1.00 0.064 3912 97.6 94.8
  1. aIndex weight for the genotype of the monogenic trait
  2. bMonths of selection response lost for the polygenic trait in generation 20, compared to the genetic level of genomic selection (GS) with b2 = 0
  3. cFrequency of the desired allele in generation 20
  4. dMean inbreeding coefficient in generation 20
  5. eCumulative number of zygotes edited over 20 generations
  6. fPercentage of animals, cumulative over the 20 generations, with the desired phenotype when the desired allele is either dominant or recessive