The impact of genome editing on the introduction of monogenic traits in livestock

Table 7 Population parameters in generations 5 and 20 with an editing success of 0.20 and a survival rate of 0.20

Generation^a	Reduced response		Frequency^c	\(\overline{F}\) ^d	Procedures^e	Cumulative benefit^f
Generation^a	σ _A	Months^b	Frequency^c	\(\overline{F}\) ^d	Procedures^e	Dominant (%)	Recessive (%)
5	− 0.88	− 13.6	0.86	0.023	9974	56.6	26.0
20	− 0.99	− 15.3	1.00	0.059	12,144	89.1	81.2

^aIndex weight for the genotype of the monogenic trait was b₂ = 0.5
^bMonths of selection response lost for polygenic BV compared to the genetic level of genomic selection (GS) with b₂ = 0 in the same generation
^cFrequency of the desired allele
^dMean inbreeding coefficient
^eCumulative number of editing procedures up to the current generation
^fPercentage of animals with the desired phenotype, cumulative up to the current generation, when the desired allele is either dominant or recessive

ISSN: 1297-9686