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Table 7 Population parameters in generations 5 and 20 with an editing success of 0.20 and a survival rate of 0.20

From: The impact of genome editing on the introduction of monogenic traits in livestock

Generationa Reduced response Frequencyc \(\overline{F}\) d Procedurese Cumulative benefitf
σ A Monthsb Dominant (%) Recessive (%)
5 − 0.88 − 13.6 0.86 0.023 9974 56.6 26.0
20 − 0.99 − 15.3 1.00 0.059 12,144 89.1 81.2
  1. aIndex weight for the genotype of the monogenic trait was b2 = 0.5
  2. bMonths of selection response lost for polygenic BV compared to the genetic level of genomic selection (GS) with b2 = 0 in the same generation
  3. cFrequency of the desired allele
  4. dMean inbreeding coefficient
  5. eCumulative number of editing procedures up to the current generation
  6. fPercentage of animals with the desired phenotype, cumulative up to the current generation, when the desired allele is either dominant or recessive