Table 1 Summary of several positively selected genes detected in Chengdu Brown and Jintang Black goats
Breeds | Sweep region (Mb) | Gene | iHH12 | FST | π ratio | Traits | Molecular function |
|---|---|---|---|---|---|---|---|
CB | chr6: 34.24-34.25 | POU1F1 | 3.43 | 0.51 | 5.78 | Litter size and growth | Activates growth hormone and prolactin genes |
CB | chr6: 65.41-65.45 | GABRA2 | 6.27 | 0.61 | 3.66 | Behavior | Mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel |
CB | chr13: 65.76-65.77 | GHRH | 2.38 | 0.57 | 3.19 | Growth | Stimulates the secretion of growth hormone |
JT | chr6: 37.97-38.06 | LCORL | 13.79 | 0.47 | 3.69 | Body size | DNA-binding transcription factor activity |
JT | chr6: 70.73-70.79 | KIT | 13.39 | 0.68 | 5.10 | Coat color | Plays roles in cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis |
JT | chr13: 63.24-63.25 | ASIP | 2.19 | 0.52 | 3.15 | Coat color | Regulates melanogenesis. The binding of ASIP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanin (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) |
JT | chr22: 31.52-31.76 | MITF | 5.77 | 0.47 | 3.39 | Coat color | Regulates the expression of genes with essential roles in cell differentiation, proliferation and survival |