An eQTL in the cystathionine beta synthase gene is linked to osteoporosis in laying hens

Table 3 Summary statistics for the animals segregating at SNPs Ost106225194 and Ost112522587

Genotype at Ost106225194 and Ost112522587	^aAA/AA	^bGG/GG	P value
Egg shell thickness (mm)	0.175 ± 0.012	0.197 ± 0.011	0.23
Body weight (g)	1599 ± 19	1600 ± 28	0.97
Total eggs	301.5 ± 2.7	303.0 ± 3.3	0.62
Cortical bone density (units per mm³)	0.045 ± 0.002	0.050 ± 0.002	0.09
% as cortical bone	42.44 ± 0.85	44.46 ± 1.427	0.20
Cortical bone volume (mm³)	38.30 ± 1.80	33.27 ± 1.70	0.06
Medullary bone density (units per mm³)	0.024 ± 0.001	0.032 ± 0.003	0.009
Medullary bone volume (mm³)	42.59 ± 2.10	32.33 ± 1.62	0.001
Medullary area (mm²)	16.47 ± 0.83	14.02 ± 0.71	0.044
Total area	2440 ± 65	2311 ± 46	0.155

All the bone measurements were made on the left tibia mid-shaft. The AA/AA genotype is the genotype associated with lower bone strength. ^aN = 36; ^bN = 25

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