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Table 1 Summary of the sheep obtained with the targeted point mutations via ABEmax

From: Highly efficient generation of sheep with a defined FecBB mutation via adenine base editing

Donor sheep

10

Collected embryos

96

ABEmax-sgRNA

 Injected embryos

96

 Transferred embryos

95

Recipient sheep

18

Pregnant recipients

6

Newborns

8

 Expected defined substitution

6

 Un-defined substitution

2

  1. ABEmax: the latest version of adenine base editors; sgRNA: single guide RNA
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Genetics Selection Evolution

ISSN: 1297-9686