Mining massive genomic data of two Swiss Braunvieh cattle populations reveals six novel candidate variants that impair reproductive success

Table 6 Short list of two potential candidate causative variants for the Original Braunvieh population^a

Haplotype-region information		Gene	OMIM/OMIA	Associated disorder/gene function	Variant designation^b
Name	Approach	Gene	OMIM/OMIA	Associated disorder/gene function	Genomic position	Transcript	Coding DNA change	Protein change
OH2	Trio and pgp	TUBGCP5	608147	Proper formation of the mitotic spindles	chr2:1268426	NM_001102495.1	c.311C>A	p.Thr104Lys
OH4	Trio and pgp	LIG3	600940	Embryonic lethality	chr19:15080335	NM_001038107.2	c.2483_2484 + 4delAGGTGC	p.Lys828fs

Chr chromosome, OH OB haplotype
^aComprehensive list available in Table S5 (see Additional file 6: Table S5)
^bAccording to the reference sequence ARS-UCD1.2 [36] and NCBI Annotation Release 106 [54]

ISSN: 1297-9686