Fig. 3

In vitro gene expression of a BLG-luciferase reporter construct in MCF-7 a and CHO-K1 b cells. Constructs with the wild type G allele of rs209645844 (B allele) and an analogous construct containing the chr11: 103256256G > AA allele (B’ allele) are shown. The genomic regions used in the reporter constructs included 881 bp of the BLG promoter (relative to the transcription initiation site of transcript NM_173929.3), exon 1, intron 1, and 139 bp of exon 2. Results are means from 12 separate transfections undertaken for each construct. Bars are standard errors of the mean